Pharmacokinetics, plasma protein binding and dosage regimen of sulphadimethoxine in buffalo calves

被引：0
|
作者：
Srivastava, AK
Chaudhary, RK
Bal, MS
机构：
[1] PUNJAB AGR UNIV, DEPT PHARMACOL & TOXICOL, LUDHIANA 141004, PUNJAB, INDIA
[2] PUNJAB AGR UNIV, COLL VET SCI, DEPT CLIN & CONTINUING EDUC, LUDHIANA 141004, PUNJAB, INDIA
来源：
INDIAN JOURNAL OF ANIMAL SCIENCES | 1996年 / 66卷 / 03期
关键词：
D O I：
暂无
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
The pharmacokinetics, protein binding and dosage regimen of sulphadimethoxine were investigated in buffalo calves following a single intravenous dose of 100 mg/kg. The distribution of half-life. (t1/2 alpha), elimination half-life (t(1/2) beta) and Vd were 0.13+/-0.02 hr, 32.4+/-2.91 hr and 2.28+/-0.33 L. kg(-1) respectively. Total body clearance which represents the sum of all clearance processes and tissue/plasma (T/P) ratio were calculated to be 52.3+/-10.4 ml. kg(-1). hr(1) and 6.08+/-0.01 respectively. Sulphadimethoxine binding with plasma proteins was to the extent of 74.5+/-1.53%.
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页码：215 / 218
页数：4
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