High SARS-CoV-2 Viral Load and Low CCL5 Expression Levels in the Upper Respiratory Tract Are Associated With COVID-19 Severity

被引：22

作者：

Perez-Garcia, Felipe ^{[1
,2
,3
]}

Martin-Vicente, Maria ^{[1
,4
]}

Lia Rojas-Garcia, Rosa ^{[1
]}

Castilla-Garcia, Lucia ^{[5
]}

Jose Munoz-Gomez, Maria ^{[1
]}

Hervas Fernandez, Irene ^{[2
]}

Gonzalez Ventosa, Victoria ^{[2
]}

Joan Vidal-Alcantara, Erick ^{[1
]}

Cuadros-Gonzalez, Juan ^{[2
,3
]}

Bermejo-Martin, Jesus F. ^{[6
,7
,8
]}

Resino, Salvador ^{[1
,4
]}

Martinez, Isidoro ^{[1
,4
]}

机构：

[1] Inst Salud Carlos III, Ctr Nacl Microbiol, Unidad Infecc Viral & Inmunidad, Majadahonda, Spain

[2] Hosp Univ Principe Asturias, Serv Microbiol Clin, Madrid, Spain

[3] Univ Alcala, Fac Med, Dept Biomed & Biotecnol, Madrid, Spain

[4] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Infecciosas, Madrid, Spain

[5] Hosp Univ Principe Asturias, Serv Hematol & Hemoterapia, Madrid, Spain

[6] Inst Invest Biomed Salamanca, Grp Biomed Res Sepsis, Salamanca, Spain

[7] Hosp Univ Rio Hortega, Valladolid, Spain

[8] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp, Madrid, Spain

来源：

JOURNAL OF INFECTIOUS DISEASES | 2022年 / 225卷 / 06期

基金：

加拿大健康研究院;

关键词：

CCL5; COVID-19; death; gene expression; ICU; innate immunity; nasopharynx; SARS-CoV-2; viral load;

D O I：

10.1093/infdis/jiab604

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mucosal immune response in the upper respiratory tract is crucial for initial control of viral replication, clearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and progression of coronavirus disease 2019 (COVID-19). We analyzed SARS-CoV-2 RNA load and expression of selected immune genes in the upper respiratory tract (nasopharynx) of 255 SARS-CoV-2-infected patients and evaluated their association with severe COVID-19. SARS-CoV-2 replication in nasopharyngeal mucosa induces expression of several innate immune genes. High SARS-CoV-2 viral load and low CCL5 expression levels were associated with intensive care unit admission or death, although CCL5 was the best predictor of COVID-19 severity.

引用

页码：977 / 982

页数：6

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