Cancer and Infective Endocarditis: Characteristics and Prognostic Impact

被引:13
|
作者
Cosyns, Bernard [1 ,2 ]
Roosens, Bram [1 ]
Lancellotti, Patrizio [3 ]
Laroche, Cecile [4 ]
Dulgheru, Raluca [3 ]
Scheggi, Valentina [5 ]
Vilacosta, Isidre [6 ]
Pasquet, Agnes [7 ,8 ]
Piper, Cornelia [9 ]
Reyes, Graciela [10 ]
Mahfouz, Essam [11 ]
Kobalava, Zhanna [12 ]
Piroth, Lionel [13 ]
Kasprzak, Jaroslaw D. [14 ]
Moreo, Antonella [15 ]
Faucher, Jean-Francois [16 ]
Ternacle, Julien [17 ,18 ]
Meshaal, Marwa [19 ]
Maggioni, Aldo P. [4 ,20 ]
Iung, Bernard [21 ]
Habib, Gilbert [22 ,23 ]
EURO-ENDO Investigators Grp
机构
[1] Vrije Univ Brussel VUB, Univ Ziekenhuis Brussel UZ Brussel, Ctr Hart en Vaatziekten CHVZ, Brussels, Belgium
[2] Vrije Univ Brussel VUB, Vivo Cellular & Mol Imaging ICMI Ctr, Brussels, Belgium
[3] Univ Hosp Ctr, Cardiol Dept, Ctr Hosp Univ CHU Sart Tilman, Liege, Belgium
[4] European Soc Cardiol, EURObservat Res Programme, Antibes, France
[5] Careggi Univ Hosp, Cardiothorac & Vasc Dept, Florence, Italy
[6] Univ Complutense Madrid, Hosp Clin San Carlos, Dept Cardiol, Madrid, Spain
[7] Catholic Univ Louvain, Inst Rech Expt & Clin, Pole Rech Cardiovasc, Brussels, Belgium
[8] Clin Univ St Luc, Div Cardiol & Cardiothorac Surg, Brussels, Belgium
[9] Ruhr Univ Bochum, Clin Gen & Intervent Cardiol Angiol, Herz & Diabeteszentrum Nordrhein Westfalen NRW, Bad Oeynhausen, Germany
[10] Hosp Alta Complejidad Red El Cruce, Echo Lab Dept, Buenos Aires, DF, Argentina
[11] Mansoura Univ, Mansoura Specialized Med Hosp, Mansoura, Egypt
[12] RUDN Univ Moscow, Dept Cardiol, Rossiyskiy Univ Druzhby Narodov, Moscow, Russia
[13] Univ Burgundy, Univ Hosp, Infect Dis Dept, INSERM,CIC1432, Dijon, France
[14] Med Univ Lodz, Bieganski Hosp, Lodz, Poland
[15] ASST Grande Osped Metropolitano Niguarda, Gasperis Cardio Ctr, Milan, Italy
[16] CHU Limoges, Dept Infect Dis & Trop Med, INSERM, U1094, Limoges, France
[17] Univ Paris Est Creteil, Henri Mondor Hosp, SOS Endocardites, Cardiol Dept,DHU ATVB INSERM,U955,Team 8, Creteil, France
[18] Univ Laval, Quebec Heart & Lung Inst, Inst Univ Cardiol & Pneumol Quebec, Equipe,Team Dr Philippe Pibarot, Quebec City, PQ, Canada
[19] Cairo Univ, Cardiol Dept, Kasr Al Ainy, Cairo, Egypt
[20] Maria Cecilia Hosp, Grp Villa Maria GVM Care & Res, Cotignola, Italy
[21] Paris Diderot Univ, Bichat Hosp, AP HP, DHU Fire, Paris, France
[22] La Timone Hosp, AP HM, Cardiol Dept, Marseille, France
[23] Aix Marseille Univ, AP HM, IHU Mediterranean Infect, MEPHI,IRD, Marseille, France
来源
关键词
cancer; cardiac surgery; infective endocarditis; registry; valve disease; CLINICAL PRESENTATION; RISK; ETIOLOGY;
D O I
10.3389/fcvm.2021.766996
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The interplay between cancer and IE has become of increasing interest. This study sought to assess the prevalence, baseline characteristics, management, and outcomes of IE cancer patients in the ESC EORP EURO-ENDO registry.Methods: Three thousand and eighty-five patients with IE were identified based on the ESC 2015 criteria. Three hundred and fifty-nine (11.6%) IE cancer patients were compared to 2,726 (88.4%) cancer-free IE patients.Results: In cancer patients, IE was mostly community-acquired (74.8%). The most frequently identified microorganisms were S. aureus (25.4%) and Enterococci (23.8%). The most frequent complications were acute renal failure (25.9%), embolic events (21.7%) and congestive heart failure (18.1%). Theoretical indication for cardiac surgery was not significantly different between groups (65.5 vs. 69.8%, P = 0.091), but was effectively less performed when indicated in IE patients with cancer (65.5 vs. 75.0%, P = 0.002). Compared to cancer-free IE patients, in-hospital and 1-year mortality occurred in 23.4 vs. 16.1%, P = 0.006, and 18.0 vs. 10.2%; P < 0.001, respectively. In IE cancer patients, predictors of mortality by multivariate analysis were creatinine > 2 mg/dL, congestive heart failure and unperformed cardiac surgery (when indicated).Conclusions: Cancer in IE patients is common and associated with a worse outcome. This large, observational cohort provides new insights concerning the contemporary profile, management, and clinical outcomes of IE cancer patients across a wide range of countries.
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页数:10
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