Antiepileptic drugs and pregnancy: brain malformations in rats prenatally exposed to lamotrigine, vigabatrin and valproate

被引：1
|
作者：
Manent, Jean-Bernard [1 ]
Ben-Ari, Yehezkel [1 ]
Represa, Alfonso [1 ]
机构：
[1] INSERM, Unite 901, Inst Neurobiol Mediterranee, F-13009 Marseille, France
来源：
EPILEPSIES | 2008年 / 20卷 / 01期
关键词：
antiepileptic drug; development; epilepsy; neuronal migration; pregnancy;
D O I：
10.1684/epi.2008.0136
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The treatment of epilepsy during pregnancy entails a number of concerns. While maternal seizures may adversely affect maternal and fetal outcome, prenatal exposure to antiepileptic drugs may increase the incidence of congenital abnormalities and affect postnatal cognitive development. In two recent studies, we have reported an increased incidence of cortical and hippocampal malformations in rats exposed to lamotrigine, vigabatrin and valproate during embryonic life. These results, as well as other experimental data, are presented here and their clinical relevance and implications are discussed.
引用
收藏
页码：27 / 32
页数：6
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