Recent Advances inn Small-Molecule HIV-1 Inntegrase Inhibitors

被引：5
|
作者：
Zhang, Chao [1 ]
Xie, Qian [1 ]
Wan, Chi Cheong [2 ]
Jin, Zhe [1 ]
Hu, Chun [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China
[2] Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Peoples R China
来源：
CURRENT MEDICINAL CHEMISTRY | 2021年 / 28卷 / 24期
基金：
美国国家科学基金会;
关键词：
AIDS; integrase; HIV-1 integrase inhibitors; anti-AIDS drugs  dual inhibitors; allosteric integrase inhibitors; IMMUNODEFICIENCY-VIRUS TYPE-1; STRAND TRANSFER INHIBITORS; DIKETO ACID-DERIVATIVES; INTEGRASE INHIBITORS; REVERSE-TRANSCRIPTASE; DUAL INHIBITORS; RIBONUCLEASE H; ACTIVE-SITE; TENOFOVIR ALAFENAMIDE; BIOLOGICAL EVALUATION;
D O I：
10.2174/0929867328666210114124744
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
HIV-1 integrase catalyzed the insertion of viral DNA into the genome of human cells in the process of retrotranscription. Integrase is an attractive target for HIV-1 treatment due to the lack of its homologue in human cells and its vital role in HIV-1 replication. Although major progress in the development of HIV-1 integrase inhibitors has been made, some thorny problems, such as drug resistance, led to the further study of HIV-1 integrase inhibitors. This review briefly discussed the structure, function, and mechanism of catalysis of HIV-1 integrase and made a different conclusion for recent advances in small-molecule inhibitors of HIV-1 integrase.
引用
收藏
页码：4910 / 4934
页数：25
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