Regulation of the aspartate and alanine aminotransferases in humans and rodents.

被引：0

作者：

Aggerbeck, M ^{[1
]}

Beurton, F ^{[1
]}

Tomkiewicz, C ^{[1
]}

Garlatti, M ^{[1
]}

Plée-Gautier, E ^{[1
]}

Antoine, B ^{[1
]}

Forest, C ^{[1
]}

Muzeau, F ^{[1
]}

Barouki, R ^{[1
]}

机构：

[1] Ctr Univ St Peres, INSERM U490, F-75006 Paris, France

来源：

BIOCHEMISTRY AND MOLECULAR BIOLOGY OF VITAMIN B6 AND PQQ-DEPENDENT PROTEINS | 2000年

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have studied the regulation of transaminase gene expression by hormones and drugs in humans and rodents. In rodents, most of the regulation is hormonal and is consistent with the role of these enzymes in gluconeogenesis. In humans, these genes are up-regulated by drugs such as fibrates, which may partially account for the increase in the activities in serum observed in some treated patients. Interestingly, fibrates down-regulate these genes in the rat, suggesting that there are important differences in the regulation of gene expression between rodents and humans.

引用

页码：29 / 34

页数：6

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