Oxytocin modulates hemodynamic responses to monetary incentives in humans

被引:14
|
作者
Mickey, Brian J. [1 ,2 ,3 ]
Heffernan, Joseph [2 ]
Heisel, Curtis [2 ]
Pecina, Marta [1 ,2 ]
Hsu, David T. [1 ,2 ,4 ]
Zubieta, Jon-Kar [1 ,2 ,3 ]
Love, Tiffany M. [1 ,2 ,3 ]
机构
[1] Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Mol & Behav Neurosci Inst, Ann Arbor, MI 48109 USA
[3] Univ Utah, Sch Med, Dept Psychiat, Salt Lake City, UT 84112 USA
[4] Stony Brook Sch Med, Dept Psychiat, Stony Brook, NY USA
关键词
Oxytocin; Reward; FMRI; VENTRAL TEGMENTAL AREA; INCREASES EXTRACELLULAR DOPAMINE; EVENT-RELATED FMRI; NUCLEUS-ACCUMBENS; INTRANASAL OXYTOCIN; HUMAN BRAIN; REWARD ANTICIPATION; PENILE ERECTION; SEX-DIFFERENCES; MALE RATS;
D O I
10.1007/s00213-016-4423-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Oxytocin is a neuropeptide widely recognized for its role in regulating social and reproductive behavior. Increasing evidence from animal models suggests that oxytocin also modulates reward circuitry in non-social contexts, but evidence in humans is lacking. We examined the effects of oxytocin administration on reward circuit function in 18 healthy men as they performed a monetary incentive task. The blood oxygenation level-dependent (BOLD) signal was measured using functional magnetic resonance imaging in the context of a randomized, double-blind, placebo-controlled, crossover trial of intranasal oxytocin. We found that oxytocin increases the BOLD signal in the midbrain (substantia nigra and ventral tegmental area) during the late phase of the hemodynamic response to incentive stimuli. Oxytocin's effects on midbrain responses correlated positively with its effects on positive emotional state. We did not detect an effect of oxytocin on responses in the nucleus accumbens. Whole-brain analyses revealed that oxytocin attenuated medial prefrontal cortical deactivation specifically during anticipation of loss. Our findings demonstrate that intranasal administration of oxytocin modulates human midbrain and medial prefrontal function during motivated behavior. These findings suggest that endogenous oxytocin is a neurochemical mediator of reward behaviors in humans-even in a non-social context-and that the oxytocinergic system is a potential target of pharmacotherapy for psychiatric disorders that involve dysfunction of reward circuitry.
引用
收藏
页码:3905 / 3919
页数:15
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