Characterization of the impurities and isomers in cefetamet pivoxil hydrochloride by liquid chromatography/time-of-flight mass spectrometry and ion trap mass spectrometry
被引:8
|
作者:
Wang, Dandan
论文数: 0引用数: 0
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机构:
Zhejiang Univ Technol, Hangzhou 310004, Zhejiang, Peoples R China
Zhejiang Inst Food & Drug Control, Hangzhou 310004, Zhejiang, Peoples R ChinaZhejiang Univ Technol, Hangzhou 310004, Zhejiang, Peoples R China
Wang, Dandan
[1
,2
]
Wang, Fan
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机构:
Zhejiang Univ, Sch Med, Hangzhou 310004, Zhejiang, Peoples R ChinaZhejiang Univ Technol, Hangzhou 310004, Zhejiang, Peoples R China
Wang, Fan
[3
]
Wang, Jian
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机构:
Zhejiang Inst Food & Drug Control, Hangzhou 310004, Zhejiang, Peoples R ChinaZhejiang Univ Technol, Hangzhou 310004, Zhejiang, Peoples R China
Wang, Jian
[2
]
机构:
[1] Zhejiang Univ Technol, Hangzhou 310004, Zhejiang, Peoples R China
[2] Zhejiang Inst Food & Drug Control, Hangzhou 310004, Zhejiang, Peoples R China
[3] Zhejiang Univ, Sch Med, Hangzhou 310004, Zhejiang, Peoples R China
Liquid chromatography/quadrupole time-of-flight mass spectrometry;
Liquid chromatography/ion trap mass spectrometry;
Cefetamet pivoxil hydrochloride;
Impurity and isomer;
Characterization;
RAPID IDENTIFICATION;
D O I:
10.1016/j.jpba.2015.03.013
中图分类号:
O65 [分析化学];
学科分类号:
070302 ;
081704 ;
摘要:
Ten impurities and isomers in cefetamet pivoxil hydrochloride drug substance made in China were separated and identified by HPLC-MSn (TOF and TRAP). Their fragmentation patterns and structural assignment were studied based on the HPLC-MSn data. Among the ten impurities and isomers, impurity VII was isolated by preparative HPLC, and its structure was confirmed by H-1 NMR data. (C) 2015 Elsevier B.V. All rights reserved.
机构:
Zhejiang Univ Technol, Hangzhou 310014, Zhejiang, Peoples R China
Zhejiang Inst Food & Drug Control, Hangzhou 310052, Zhejiang, Peoples R ChinaZhejiang Univ Technol, Hangzhou 310014, Zhejiang, Peoples R China
Wang, Jian
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h-index:
机构:
Xu, Yu
Wen, Chunmei
论文数: 0引用数: 0
h-index: 0
机构:
Zhejiang Univ Technol, Hangzhou 310014, Zhejiang, Peoples R ChinaZhejiang Univ Technol, Hangzhou 310014, Zhejiang, Peoples R China
Wen, Chunmei
Wang, Zhijian
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机构:
Zhejiang Inst Food & Drug Control, Hangzhou 310052, Zhejiang, Peoples R ChinaZhejiang Univ Technol, Hangzhou 310014, Zhejiang, Peoples R China
机构:
Natl Inst Metrol China, Div Chem Metrol & Analyt Sci, Beijing 100013, Peoples R ChinaNatl Inst Metrol China, Div Chem Metrol & Analyt Sci, Beijing 100013, Peoples R China
Kang, Ma
Yang, Yanan
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机构:
Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Substance & Funct Nat Med, Beijing 100050, Peoples R China
Peking Union Med Coll, Beijing 100050, Peoples R ChinaNatl Inst Metrol China, Div Chem Metrol & Analyt Sci, Beijing 100013, Peoples R China
Yang, Yanan
Zhang, Peicheng
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Substance & Funct Nat Med, Beijing 100050, Peoples R China
Peking Union Med Coll, Beijing 100050, Peoples R ChinaNatl Inst Metrol China, Div Chem Metrol & Analyt Sci, Beijing 100013, Peoples R China
Zhang, Peicheng
Dong, Jing
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h-index: 0
机构:
Shimadzu Int Trade Ltd Shanghai, Ctr Anal Beijing, Beijing 100020, Peoples R ChinaNatl Inst Metrol China, Div Chem Metrol & Analyt Sci, Beijing 100013, Peoples R China