Aspirin desensitization

被引：0
|
作者：
Weber, R. [1 ,4 ]
Trautmann, A. [2 ]
Randerath, W. [5 ]
Heppt, W. [1 ]
Hosemann, W. [3 ]
机构：
[1] Stadt Klinikum Karlsruhe, HNO Klin, Karlsruhe, Germany
[2] Univ Klinikum Wurzburg, Klin & Poliklin Dermatol Venerol & Allergol, Wurzburg, Germany
[3] Ernst Moritz Arndt Univ Greifswald, Univ HNO Klin, Greifswald, Germany
[4] UKGM, Nasenzentrum Marburg, Univ HNO Klin, Marburg, Germany
[5] Krankenhaus Bethanien gGmbH, Klin Pneumol & Allergol, Zentrum Schlaf & Beatmungsmed, Solingen, Germany
来源：
HNO | 2012年 / 60卷 / 04期
关键词：
Rhinitis; Sinusitis; Bronchial asthma; Aspirin desensitization; Nasal polyps; EXACERBATED RESPIRATORY-DISEASE; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; LEUKOTRIENE-MODIFIER DRUGS; ENDONASAL SINUS SURGERY; LONG-TERM TREATMENT; INDUCED ASTHMA; NATURAL-HISTORY; NASAL POLYPOSIS; CHRONIC RHINOSINUSITIS; SECONDARY PREVENTION;
D O I：
10.1007/s00106-011-2444-3
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Aspirin desensitization has established itself as an additional therapy option in the treatment of aspirin- exacerbated respiratory disease, recurrent chronic rhinosinusitis and nasal polyps. Inpatient treatment is strongly recommended due to the risk of life-threatening side effects. In addition, the necessary requirements, indications and contraindications should be carefully considered from a medicolegal perspective. A maintenance dose of 300 ( -500) mg ASS is currently recommended. Indications include persisting symptoms despite intensive medical care and/or recurrent nasal polyps, leading to recurrent sinus operations and/or the need to take systemic corticosteroids in order to control nasal symptoms or asthma. If ASS intake is interrupted for more than 48 h, aspirin desensitization should be resumed to prevent renewed intolerance reactions.
引用
收藏
页码：369 / 382
页数：14
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