Iron-Catalyzed Dehydration of Aldoximes to Nitriles Requiring Neither Other Reagents Nor Nitrile Media

被引：32

作者：

Hyodo, Kengo ^{[1
]}

Kitagawa, Saki ^{[1
]}

Yamazaki, Masayuki ^{[1
]}

Uchida, Kingo ^{[1
]}

机构：

[1] Ryukoku Univ, Fac Sci & Technol, Dept Chem Mat, Otsu, Shiga 5202194, Japan

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2016年 / 11卷 / 09期

关键词：

aldehydes; aldoximes; dehydration; iron-catalyst; nitrile synthesis; HIGH-YIELD CONVERSION; HYDROXYLAMINE HYDROCHLORIDE; BECKMANN REARRANGEMENT; HETEROGENEOUS CATALYST; FACILE DEHYDRATION; ACTIVE CATALYSTS; HIGHLY EFFICIENT; METHYL ARENES; STRAIN OXB-1; ALDEHYDES;

D O I：

10.1002/asia.201600085

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The dehydration of aldoximes is an environmentally benign reaction affording the desired nitrile and water as a by-product. However, most of the reported catalytic dehydration reactions of aldoximes require a solvent containing nitrile to synthesize the corresponding nitrile compounds. Inspired by recent reports on the enzymatic synthesis under nitrile-free conditions, we here describe that a simple iron salt catalyzes the dehydration of aldoximes requiring neither other reagents nor nitrile media. Our method can be applied to the one-pot synthesis of nitiriles from aldehydes.

引用

页码：1348 / 1352

页数：5