Nanotemplating of Biodegradable Polymer Membranes for Constant-Rate Drug Delivery

被引：37
|
作者：
Bernards, Daniel A. [1 ,2 ]
Desai, Tejal A. [1 ,2 ]
机构：
[1] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA
[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA
来源：
ADVANCED MATERIALS | 2010年 / 22卷 / 21期
基金：
美国国家卫生研究院;
关键词：
BLOCK-COPOLYMER; POLYELECTROLYTE MULTILAYERS; NANOTUBE ARRAYS; TIO2; NANOTUBES; DIFFUSION; ALUMINA; IMMUNOISOLATION; SEPARATION; COATINGS; BEHAVIOR;
D O I：
10.1002/adma.200903439
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A nanoporous biodegradable polymer (polycaprolactone) is fabricated utilizing a zinc oxide nanotemplate (see figure). Chemical characterization verifies removal of the template, and preliminary tests on the cytotoxicity demonstrate basic bio-compatibility. Diffusion of a model small molecule and a protein are shown to be first and zero order, respectively, indicating these nanoporous membranes may be useful for controlled release of protein-based therapeutics.
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页码：2358 / 2362
页数：5
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