Correlation of body temperature with protection against staphylococcal enterotoxin B exposure and use in determining vaccine dose-schedule

被引：12

作者：

Boles, JW ^{[1
]}

Pitt, MLM ^{[1
]}

LeClaire, RD ^{[1
]}

Gibbs, PH ^{[1
]}

Ulrich, RG ^{[1
]}

Bavari, S ^{[1
]}

机构：

[1] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA

来源：

VACCINE | 2003年 / 21卷 / 21-22期

关键词：

bacterial superantigens; vaccine; telemetry; biomarkers; aerosol;

D O I：

10.1016/S0264-410X(03)00222-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunoprotective potential of a recombinant vaccine against the incapacitating effect of aerosolized staphylococcal enterotoxin B (SEB) in nonhuman primates is reported. SEB belongs to a family of structurally related superantigens responsible for serious, life threatening pathologies. Injecting the recombinant SEB vaccine did not induce temperature elevation in rhesus monkeys, a classical symptom of toxic-shock syndrome. No temperature elevation was noted following injection with control tetanus toxoid. In addition to 100% survival, we observed a clear correlation between vaccine dose and mitigation of temperature elevation after a lethal SEB aerosol challenge. We conclude that the recombinant SEB vaccine is non-pyrogenic and that monitoring changes in body temperature is an important biomarker of toxic shock in a primate animal model. Published by Elsevier Science Ltd.

引用

页码：2791 / 2796

页数：6