Decision-making impairment in schizophrenia: Relationships with positive symptomatology

被引：27

作者：

Struglia, F.

Stratta, P. ^{[2
]}

Gianfelice, D. ^{[3
]}

Pacifico, R.

Riccardi, I.

Rossi, A. ^{[1
,3
]}

机构：

[1] Univ Aquila, Dipartimento Med Sperimentale, Inst Expt Med, I-67100 Laquila, Italy

[2] ASL 1 Aquila, Dept Mental Hlth, Laquila, Italy

[3] Inst Clin Res, Pescara, Italy

来源：

NEUROSCIENCE LETTERS | 2011年 / 502卷 / 02期

关键词：

Decision-Making; Iowa Gambling Task; Schizophrenia; Positive symptoms; VENTROMEDIAL PREFRONTAL CORTEX; IOWA GAMBLING TASK; OBSESSIVE-COMPULSIVE DISORDER; ORBITOFRONTAL CORTEX; 1ST-EPISODE; PSYCHOSIS; DOPAMINE; DEFICITS; DISSOCIATION; HYPOTHESIS;

D O I：

10.1016/j.neulet.2011.07.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Abnormal decision-making (DM) performance has been reported in several neurobehavioral disorders such as schizophrenia, addiction, and obsessive compulsive disorders. The exploration of DM correlates in terms of symptom formation may add more knowledge about the meanings of DM performance in schizophrenia. We examined the Iowa Gambling Task (IGT) and its relationship with clinical symptoms, evaluated by Positive and Negative Symptom Scale (PANSS), in 40 schizophrenic patients and 20 controls. Schizophrenic patients did worse on IGT performance with a significant difference between the two groups in Net Score. PANSS positive symptoms were negatively correlated with Net Score and advantageous choices and directly with disadvantageous choices. Results suggest that persons with schizophrenia display a pattern of compromised DM related to positive symptoms. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：80 / 83

页数：4

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