Nanofibers of silk fibroin controlled by the crystallization of polyethylene glycol in frozen solution

被引：1

作者：

Chen, Cong-heng ^{[1
]}

Zhao, Juan ^{[1
]}

Yang, Zhou ^{[1
]}

Sun, Qing ^{[1
]}

Zhou, Ping ^{[1
]}

机构：

[1] Fudan Univ, Dept Macromol Sci, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China

来源：

CHINESE JOURNAL OF POLYMER SCIENCE | 2017年 / 35卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Silk fibroin; Polyethylene glycol; Freezing; Phase separation; Crystallization; CONFORMATION TRANSITION KINETICS; FREEZING METHODS; DRUG-DELIVERY; PROTEIN; PEGYLATION; STABILITY; NANOPARTICLES; POLYMER;

D O I：

10.1007/s10118-017-1974-x

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The conformation of silk fibroin (SF) frozen with polyethylene glycol (PEG) at a molecular weight from 2 kDa to 20 kDa and a mass ratio of PEG:SF from 1:5 to 10:1 was studied by spectral and microscopic methods. It is found that the conformation transition of SF from random coil to beta-sheet could be induced by the stress resulting from PEG crystallization at -20 A degrees C, and greatly depended on the cooling rate, PEG:SF mass ratio and PEG molecular weight. These findings provide a new method for the preparation of desired SF nanofibers.

引用

页码：1373 / 1380

页数：8

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