Multiadaptor proteins of the 4.1 family and RanBP9 as potential interaction partners for VARP, a Rab21 GTPase guanine nucleotide exchange factor

被引：1

作者：

Palgova, I. V. ^{[1
]}

Korobko, E. V. ^{[1
,2
]}

Korobko, I. V. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Inst Gene Biol, Moscow 119334, Russia

[2] Univ Oslo, Ctr Med Studies Russia, Moscow 119334, Russia

来源：

MOLECULAR BIOLOGY | 2007年 / 41卷 / 06期

基金：

俄罗斯基础研究基金会;

关键词：

VARP; early endocytosis; protein interaction cloning in yeast; 4.1 protein family; RanPB9;

D O I：

10.1134/S0026893307060088

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

VARP is a new VPS9 domain-containing protein that acts as a guanine nucleotide exchange factor for small GTPases Rab21 and Rab5, which regulate early endocytosis. The molecular mechanisms regulating the VARP activity and intracellular localization are unknown. By protein interaction cloning in yeasts, multiadaptor proteins of the 4.1 family and RanBP9 were isolated as putative interaction partners of VARP. The interaction with these proteins was assumed to play an important role in the intracellular localization of VARP and its function in early endocytosis.

引用

页码：920 / 923

页数：4

共 7 条

[1] Multiadaptor proteins of the 4.1 family and RanBP9 as potential interaction partners for VARP, a Rab21 GTPase guanine nucleotide exchange factor
I. V. Palgova
E. V. Korobko
I. V. Korobko
Molecular Biology, 2007, 41 : 920 - 923
[2] Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics
Zhang, XJ
He, X
Fu, XY
Chang, ZJ
JOURNAL OF CELL SCIENCE, 2006, 119 (06) : 1053 - 1062
[3] Identification of novel proteins, possible interaction partners for guanine nucleotide exchange factor varp
P. N. Vikhreva
E. V. Korobko
I. V. Korobko
Doklady Biochemistry and Biophysics, 2009, 429 : 323 - 325
[4] Identification of novel proteins, possible interaction partners for guanine nucleotide exchange factor varp
Vikhreva, P. N.
Korobko, E. V.
Korobko, I. V.
DOKLADY BIOCHEMISTRY AND BIOPHYSICS, 2009, 429 (01) : 323 - 325
[5] Lpg0393 of Legionella pneumophila Is a Guanine-Nucleotide Exchange Factor for Rab5, Rab21 and Rab22
Sohn, Young-Sik
Shin, Ho-Chul
Park, Wei Sun
Ge, Jianning
Kim, Chan-Hee
Lee, Bok Luel
Heo, Won Do
Jung, Jae U.
Rigden, Daniel John
Oh, Byung-Ha
PLOS ONE, 2015, 10 (03):
[6] The Rab5 guanine nucleotide exchange factor Vps9p is monoubiquitinated and is required for the efficient trafficking of proteins through the endocytic pathway
Davies, BA
Topp, JD
Sfeir, AJ
Tall, GG
Carney, DS
Friedberg, AS
Horazdovsky, BF
MOLECULAR BIOLOGY OF THE CELL, 2002, 13 : 6A - 6A
[7] Differential interaction of the Ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor
Herrmann, C
Horn, G
Spaargaren, M
Wittinghofer, A
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (12) : 6794 - 6800

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