A Portable Fiber Based Dual-Wavelength Confocal Raman Spectroscopy System

被引：0
|
作者：
Zhang, Ruochong [1 ]
Bi, Renzhe [1 ]
Rajarahm, Poongkulali [1 ]
Dinish, U. S. [1 ]
Olivo, Malini [1 ]
机构：
[1] ASTAR, Inst Bioengn & Bioimaging, Translat Biophoton Lab, 11 Biopolis Way, Singapore 138667, Singapore
来源：
OPTICAL BIOPSY XX: TOWARD REAL-TIME SPECTROSCOPIC IMAGING AND DIAGNOSIS | 2022年 / 11954卷
关键词：
confocal Raman spectroscopy; fiber-based; handheld; fingerprint; high wavenumber; noninvasive; skin diagnosis; SKIN; FILAGGRIN; SEVERITY;
D O I：
10.1117/12.2607863
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A fiber-based dual-wavelength confocal Raman spectroscopy with handheld probe for skin measurement was introduced. The system achieved fast and noninvasive spectra acquisition at different depths of skin in both fingerprint region and high wavenumber region. The system performance was benchmarked with a commercial confocal Raman system to prove its reliable spectra quality. Moreover, a case study on eczema patient showed that our system is able to differentiate spectra from patient and healthy volunteers, indicating its great potential to facilitate future diagnosis in skin diseases.
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页数：4
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