A new strategy for the synthesis of 4,6-di-tert-butyl-2,2-dipentyl-2,3-dihydro-5-benzofuranol (BO-653), a potent antiatherogenic antioxidant

被引：7
|
作者：
Murakata, Masatoshi [1 ]
Kimura, Masahiro [1 ]
机构：
[1] Chugai Pharmaceut Co Ltd, API Proc Dev Dept, Kita Ku, Tokyo 1158543, Japan
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 38期
关键词：
GRIGNARD-REAGENT; BROMIDE; DESIGN; CONSTITUTION; MECHANISM; ETHER;
D O I：
10.1016/j.tetlet.2010.07.035
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient alternative route to 4,6-di-tert-butyl-2,2-dipentyl-2,3-dihydro-5-benzofuranol (BO-653), a potent antiatherogenic antioxidant, has been developed by the application of the base-promoted dienone-phenol rearrangement reaction. A decisive effect of MgBr(2) in the reaction of Grignard reagents is also described. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4950 / 4952
页数：3
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