Amino Acids Supplementation for the Milk and Milk Protein Production of Dairy Cows

Simple Summary The composition of milk not only has nutritional implications, but is also directly related to the income of dairy producers. As regards milk's composition, concerns around milk protein have emerged from the increased consumption of casein products. The synthesis of proteins in milk is a highly complex and high-cost process, because the conversion efficiency of dietary protein to milk protein is very low in dairy cows. Thus, some studies have increased milk protein by using protein supplements or a single amino acid (AA) supply. AAs are the building blocks of protein, and can also stimulate the protein synthetic pathway. This review mainly concerns the use of AAs for producing milk protein in high-producing dairy cows, particularly with methionine, lysine, and histidine. Understanding the mechanisms of AAs will help to promote milk protein synthesis in the dairy industry. As the preference of consumers for casein products has increased, the protein content of milk from dairy cows is drawing more attention. Protein synthesis in the milk of dairy cows requires a proper supply of dietary protein. High protein supplementation may help to produce more milk protein, but residues in feces and urine cause environmental pollution and increase production costs. As such, previous studies have focused on protein supplements and amino acid (AA) supply. This review concerns AA nutrition for enhancing milk protein in dairy cows, and mainly focuses on three AAs: methionine, lysine, and histidine. AA supplementation for promoting protein synthesis is related to the mammalian target of rapamycin (mTOR) complex and its downstream pathways. Each AA has different stimulating effects on the mTOR translation initiation pathway, and thus manifests different milk protein yields. This review will expand our understanding of AA nutrition and the involved pathways in relation to the synthesis of milk protein in dairy cows.