Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein

被引：41
|
作者：
Li, Huan-Qiu [1 ]
Xue, Jia-Yu [1 ]
Shi, Lei [1 ]
Gui, Shan-Ying [1 ]
Zhu, Hai-Liang [1 ]
机构：
[1] Nanjing Univ, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 43卷 / 03期
基金：
中国国家自然科学基金;
关键词：
deoxybenzoin derivatives; metal complexes; antibacterial activity; structure-activity relationships;
D O I：
10.1016/j.ejmech.2007.05.013
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of deoxybenzoin derivatives from genistein were synthesized and their structures were elucidated by H-1 NMR, mass spectral data and micro analyses. The structures of 2, 7 and 10 were determined by single-crystal X-ray analysis. These obtained compounds were evaluated for their assayed antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence and Staphylococcus aureus) and antifungal (Aspergillus niger, Candida albicans and Trichophyton rubrum) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium. bromide) method. Most compounds have displayed comparable antibacterial activity against bacterial. On the basis of the biological results, structure-activity relationships are discussed. (c) 2007 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：662 / 667
页数：6
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