Effects of CCR2 and CCR5 polymorphisms on HIV-1 infection in Thai females

被引：12
|
作者：
Wichukchinda, Nuanjun [2 ]
Nakayama, Emi E. [1 ]
Rojanawiwat, Archawin [2 ]
Pathipvanich, Panita [3 ]
Auwanit, Rattana [2 ]
Vongsheree, Suthon [2 ]
Ariyoshi, Koya [4 ]
Sawanpanyalert, Pathom [2 ]
Shioda, Tatsuo [1 ]
机构：
[1] Osaka Univ, Res Inst Microbial Dis, Dept Viral Infect, Suita, Osaka 5650871, Japan
[2] Natl Inst Hlth, Minist Publ Hlth, Dept Med Sci, Nonthaburi, Thailand
[3] Lampang Hosp, Day Care Ctr, Lampang, Thailand
[4] Nagasaki Univ, Inst Trop Med, Nagasaki 852, Japan
来源：
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2008年 / 47卷 / 03期
关键词：
CCR2; CCR5; SNPs; HIV-1; infection; Thai;
D O I：
10.1097/QAI.0b013e318162caab
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Polymorphisms in CCR2 and CCR5 genes reportedly affect HIV-1 transmission and disease progression in HIV-1-infected individuals. In the study presented here, we examined the effects of CCR2 and CCR5 polymorphisms on HIV-1 transmission in 74 Thai females who were exposed to HIV but seronegative (ESN) and in 347 HIV-seropositive females. We found that the combination of 2 non-synonymous substitutions, CCR2 V641 and CCR5 G316A, tended to occur more frequently in ESN females (2 of 74) than in HIV-1-infected females (I of 347) (P = 0.08). This suggested that non-synonymous substitution in the CCR5 gene also affects HIV-1 transmission in an Asian population in which the CCR5-Delta 32 is very rare.
引用
收藏
页码：293 / 297
页数：5
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