Sequence specificity of DNA cleavage by bisnetropsin-linked hydroxamic acid-metal complexes: Highly specific cleavage by ferrous complexes

被引：0

作者：

Hashimoto, S ^{[1
]}

Nakamura, Y ^{[1
]}

机构：

[1] Sci Univ Tokyo, Dept Biol Sci & Technol, Noda, Chiba 2788510, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1998年 / 46卷 / 12期

关键词：

DNA cleavage; hydroxamic acid; netropsin; ferrous ion; lanthanide metal; specific cleavage;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bisnetropsin-linked hydroxamic acids (BNHA) were shown to cleave DNA strands at a single residue with a preferred binding orientation in the presence of ferrous ion. In contrast, the corresponding cerium (III) complexes cleaved DNA with low sequence specificity.

引用

页码：1941 / 1943

页数：3

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