Glucose and HbA1c variability and time in range (TIR) Are these parameters important with respect to diabetes complications?

被引：0

作者：

Prattichizzo, Francesco ^{[1
,2
]}

Ceriello, Antonio ^{[1
,2
]}

机构：

[1] IRCCS Multimed, Polo Sci & Tecnol, Milan, Italy

[2] IRCCS Multimed, Polo Sci & Tecnol, Via Fantoli 16-15, I-20138 Milan, Italy

来源：

DIABETOLOGIE | 2022年

关键词：

Diabetes mellitus; Glycemic control; Diabetes complications; Glycemiarelated; Metrics; Variability; ALL-CAUSE MORTALITY; GLYCEMIC VARIABILITY; TYPE-2; ASSOCIATION; HYPOGLYCEMIA; ADULTS; IMPACT; RISK;

D O I：

10.1007/s11428-022-00969-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glycated hemoglobin (HbA1c) is the pillar of diabetes management, but does not capture blood glucose fluctuations over time. Recent data suggest that additional glucose-related metrics might improve prevention of the increased cardiovascular risk in diabetes. Variabilities in both blood glucose and HbA1cappear to represent additional, independent risk factors for diabetes complications. Continuous glucose monitoring also allows calculation of a new, intuitive metric, i.e., time in range (TIR), which is strictly related to glucose variability and is also an independent risk factor for diabetes complications. Here, we review the main findings on the influence of TIR, glucose, and HbA1cvariability on the development of complications and highlight the possible role of novel drugs in improving glucose variability.

引用

页数：6

共 50 条

[1] Glucose and HbA1c variability and time in range (TIR) Are these parameters important with respect to diabetes complications? German version
Prattichizzo, Francesco
Ceriello, Antonio
[J]. DIABETOLOGIE, 2023, 19 (03): : 361 - 369
[2] Glukose- und HbA1c-Variabilität sowie Zeit im Zielbereich (TIR)Sind diese Parameter in Bezug auf Diabeteskomplikationen von Bedeutung?Glucose and HbA1c variability and time in range (TIR)Are these parameters important with respect to diabetes complications? German version
Francesco Prattichizzo
Antonio Ceriello
[J]. Die Diabetologie, 2023, 19 : 361 - 369
[3] Glucose variability, HbA1c and microvascular complications
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[J]. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, 2016, 17 (01): : 103 - 110
[4] Glucose variability, HbA1c and microvascular complications
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[J]. Reviews in Endocrine and Metabolic Disorders, 2016, 17 : 103 - 110
[5] THE RELATIONSHIP BETWEEN TIME-IN RANGE (TIR), MEAN CGM GLUCOSE AND HBA1C IN YOUTH WITH TYPE 1 DIABETES
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[6] The Relationship of Time-in-Range (TIR) and HbA1c and the Factors That Contribute to a Better TIR
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[J]. DIABETES, 2021, 70
[7] HbA1c variability and diabetes complications: assessment and implications
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[J]. DIABETES & METABOLISM, 2023, 49 (01)
[8] Relationship Between Time in Range, Glycemic Variability, HbA1c, and Complications in Adults With Type 1 Diabetes Mellitus
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[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2022, 107 (02): : E570 - E581
[9] THE SPECTRUM OF ASSOCIATION BETWEEN HBA1C AND TIME-IN-RANGE (TIR)
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[J]. DIABETES TECHNOLOGY & THERAPEUTICS, 2020, 22 : A28 - A29
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[J]. DIABETES CARE, 2002, 25 (02) : 275 - 278

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