Association between functional polymorphism of the AVPR1b gene and polymorphism rs1293651 of the CRHR1 gene and bipolar disorder with psychotic features

Background: An association between HPA - axis disturbances and susceptibility towards depression with psychotic features has been reported. NR3C1, CRHR1 and AVPR1b are the key components of this system. We investigated the possible involvement of the polymorphisms of those genes with the susceptibility to psychotic features in the course of BP I disorder. Methods: The study was conducted on 194 patients with psychotic features in the course of BPI. Control group consisted of 732 healthy subjects. Genotyping for NR3C1, AVPR1b and CRHR1 polymorphisms was done with use of TagMan SNP Genotyping Assays. Results: The association of polymorphisms rs28536160 genotype TT of the AVPR1b gene and polymorphisms rs1293651 of CRHR1 gene with psychotic features in the course of BPI. Limitations: The main limitation of our study is the small sample size of the group of patients with psychotic features. Conclusions: The results of our study suggest that the studied polymorphisms may increase susceptibility for obtaining psychotic features in the course of BP I. (C) 2012 Elsevier B.V. All rights reserved.