Colchicine-induced neuromyopathy in a patient with chronic renal failure:: the role of clarithromycin

被引：0
|
作者：
van der Velden, W. [2 ]
Huussen, J. [1 ]
ter Laak, H. [3 ]
de Sevaux, R. [1 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Nephrol, NL-6500 HB Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Dept Haematol, NL-6500 HB Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Med Ctr, Dept Pathol, NL-6500 HB Nijmegen, Netherlands
来源：
NETHERLANDS JOURNAL OF MEDICINE | 2008年 / 66卷 / 05期
关键词：
clarithromycin; colchicine; CYP(3)A(4); neuromyopathy; P-glycoprotein; simvastatin;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Neuromyopathy is a rare side effect of chronic colchicine therapy, most often occurring in patients with chronic renal failure. Drugs interacting with colchicine metabolism through CYP(3)A(4) and P-glycoprotein can accelerate accumulation and toxicity. We describe a case of an interaction between clarithromycin and colchicine resulting in acute neuromyopathy, and we conclude that combined use of macrolides and colchicine should be avoided.
引用
收藏
页码：204 / 206
页数：3
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