A convenient preparation of β-acetamido substituted tryptamine derivatives

被引：8
|
作者：
Boisbrun, M [1 ]
Vassileva, E [1 ]
Raoul, M [1 ]
Laronze, JY [1 ]
Sapi, J [1 ]
机构：
[1] Univ Reims, Fac Pharm, Isolement Struct Transformat & Synth Subst Nat IF, CNRS,UMR 6013, F-51096 Reims, France
来源：
MONATSHEFTE FUR CHEMIE | 2003年 / 134卷 / 12期
关键词：
tryptamine derivatives; heterocycles; serotonine receptor ligand; protecting groups; chemoselectivity;
D O I：
10.1007/s00706-003-0068-3
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In view of finding new 5-HT6 receptor ligands various beta-acetamido substituted tryptamine and N,N-dimethyltryptamine derivatives were synthesized from a common intermediate. A trimolecular condensation between indole, Meldrum's acid and N-phthalimidoacetaldehyde followed by careful deprotection and functional group manipulations were proposed for this purpose.
引用
收藏
页码：1641 / 1649
页数：9
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