Analysis of Ipsilateral Breast Tumour Recurrence in Breast Cancer After Breast Conservation Surgery in Tertiary Care Referral Cancer Center Cohort Analysis

This non-randomised, cohort analysis was conducted to analyse the ipsilateral breast tumour recurrence after breast conservation surgery and the factors affecting the recurrences. The study reflects a recurrence rate of 3.2% at 5 years. A non-randomised, cohort analysis of 248 patients was conducted to analyse the ipsilateral breast tumour recurrence after breast conservation surgery and the factors affecting the recurrences. Patients with T1-T3 lesion who underwent breast conservation surgery with SLNB/axillary clearance between January 2014 and May 2018 in Manipal Comprehensive Cancer Centre were enrolled in the study. All of them received adjuvant radiotherapy. The median follow up was 43 months. In our study 8 patients developed recurrence (3.22%) The highest rate of recurrence was noted in triple negative breast cancer (75%) followed by Luminal B (25%). Her2neu rich and Luminal A groups had no local recurrence. Higher recurrence was noted in node-positive patients and post neo-adjuvant group (62.5%).Two patients had systemic recurrence along with local recurrence and one succumbed to the disease. The 5-year disease-free survival was 97% with a median follow-up of 43 months, 95% CI (41.339-44.661). Our studies demonstrated a recurrence rate of 3.22% with the highest recurrence in the triple negative group (75%). The other factors affecting recurrence were nodal disease, bulky tumours downsized after neo-adjuvant chemotherapy and quadrant of the breast.