Histone methylations in heart development, congenital and adult heart diseases

被引：1
|
作者：
Zhang, Qing-Jun [1 ,2 ]
Liu, Zhi-Ping [1 ,2 ]
机构：
[1] UT Southwestern Med Ctr, Dept Internal Med, Div Cardiol, Dallas, TX 75350 USA
[2] UT Southwestern Med Ctr, Mol Biol, Dallas, TX 75350 USA
来源：
EPIGENOMICS | 2015年 / 7卷 / 02期
关键词：
cardiac hypertrophy; congenital heart disease; demethylase; epigenetics; heart development; histone; methyltransferase; GENE-EXPRESSION; TRANSCRIPTION FACTOR; CHROMATIN-STRUCTURE; CARDIAC-FUNCTION; KABUKI SYNDROME; MOUSE HEART; LYSINE; 9; METHYLTRANSFERASE; H3; DEMETHYLASE;
D O I：
10.2217/EPI.14.60
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Heart development comprises myocyte specification, differentiation and cardiac morphogenesis. These processes are regulated by a group of core cardiac transcription factors in a coordinated temporal and spatial manner. Histone methylation is an emerging epigenetic mechanism for regulating gene transcription. Interplay among cardiac transcription factors and histone lysine modifiers plays important role in heart development. Aberrant expression and mutation of the histone lysine modifiers during development and in adult life can cause either embryonic lethality or congenital heart diseases, and influences the response of adult hearts to pathological stresses. In this review, we describe current body of literature on the role of several common histone methylations and their modifying enzymes in heart development, congenital and adult heart diseases.
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收藏
页码：321 / 330
页数：10
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