The association study of the DRD2 gene C939T polymorphism and schizophrenia

被引：0
|
作者：
Monakhov, M. V.
Golimbet, V. E.
Chubabria, K. V.
Zykov, V. V.
Kovtun, A. L.
Karpov, V. L.
机构：
来源：
ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA | 2007年 / 107卷 / 10期
关键词：
schizophrenia; association; DRD2 single nucleotide; polimorphism;
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暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Physiological evidences and several association studies suggest that the DRD2 gene is implicated in the pathogenesis of schizophrenia. The DRD2 C939T (rs6275) single nucleotide polymorphism was genotyped in 272 patients and 362 healthy controls. An association between this polymorphism and schizophrenia was found (p=0,02), the frequency of the TT genotype being higher in patients compared to the controls (chi(2) =7,2; p=0,007; OR=1,96, 95% CI=1,2-3,2). The results obtained replicate the data of a previous study of the association between the T allele and schizophrenia.
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页码：58 / 60
页数：3
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