Partial molar properties from solute retention in supercritical fluid chromatography: thermodynamic framework, advantages, and limitations

The changes in chromatographic retention of a solute with the operating parameters such as pressure, temperature and composition of the mobile-phase fluid may be employed to measure the infinite-dilution partial molar volume of the solute in the mobile-phase fluid, the infinite-dilution partial molar enthalpy of the solute in the mobile-phase fluid, and the change of the infinite-dilution fugacity coefficient of the solute in a binary mobile-phase fluid with composition of the fluid. The theoretical background, benefits and limitations of this technique are discussed with emphasis on supercritical fluid chromatography. (C) 1998 Elsevier Science B.V. All rights reserved.