Antiestrogenic and antigenotoxic activity of bee pollen from Cystus incanus and Salix alba as evaluated by the yeast estrogen screen and the micronucleus assay in human lymphocytes

被引：32

作者：

Pinto, Barbara ^{[1
]}

Caciagli, Francesca ^{[2
]}

Riccio, Elisabetta ^{[2
]}

Reali, Daniela ^{[1
]}

Saric, Ana ^{[3
]}

Balog, Tihomir ^{[3
]}

Likic, Sasa ^{[4
]}

Scarpato, Roberto ^{[2
]}

机构：

[1] Univ Pisa, Dipartimento Patol Sperimentale Biotecnol Med Inf, I-56127 Pisa, Italy

[2] Univ Pisa, Dipartimento Biol, I-56127 Pisa, Italy

[3] Rudjer Boskovic Inst, Div Mol Med, Zagreb, Croatia

[4] Univ Zagreb, Fac Sci, Zagreb 10000, Croatia

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 09期

关键词：

Bee pollen; Antiestrogenic activity; Antigenotoxicity; Chemopreventive agents; Micronuclei; IN-VITRO; ANTIMUTAGENIC ACTIVITY; MUTAGENIC-ACTIVITY; PHENOLIC-COMPOUNDS; SAFETY EVALUATION; ANTICANCER DRUGS; GENOTOXICITY; FLAVONOIDS; ANTIOXIDANT; EXTRACT;

D O I：

10.1016/j.ejmech.2010.06.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The estrogenic/antiestrogenic activity and the genotoxicity/antigenotoxicity of bee pollen from Salix alba L and Cystus incanus L and its derivative extracts in yeast and human cells was investigated. All samples showed a marked inhibitory effect on the activity of the natural estrogen 17 beta-estradiol (higher than 90% for extracts 2) and failed to cause estrogenic activity and chromosome damage. At least one preparation from each species showed a marked antigenotoxic effect against the action of the anticancer drugs mytomicin C. bleomycin, and vincristine. Bee pollens from C. incanus and S. alba were found to be neither genotoxic nor estrogenic as well as effective estrogen inhibitors, and able to reduce the chromosome damage induced by the three cancer drugs used, thus supporting their use as a safe food supplement and future chemoprotective/chemopreventive agents. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：4122 / 4128

页数：7