The hypertriglyceridemic waist and waist-to-height ratio phenotypes and chronic kidney disease: Cross-sectional and prospective investigations

Aims: We investigated the association between two hypertriglyceridemic waist (HW) and waist-to height ratio (HWHtR) phenotypes and chronic kidney disease (CKD) using cross sectional and prospective analysis. Methods: Data of 12,012 individuals (44% men) of the Tehran Lipid and Glucose Study (TLGS) at two phases [(1999-2001) and (2002-2005)], were used for cross-sectional analysis. This population was followed until 2014 with median follow-up 12.4 years (95% confidence interval (CI): 11.8; 12.4). The data of 8225 individuals (45% men) were used for prospective analysis. The outcome was the development of CKD defined as estimated glomerular filtration rate (eGFR) <60 mL/min/ 1.73 m(2). The HW phenotype was defined as waist circumference (WC) >90 cm in men and >85 cm in women, along with TGs >2.0 mmol/L. The HWHtR phenotype was defined as waist-to-height ratio (WHtR) >0.5 and TGs >2 mmol/L. Multivariable logistic and Cox regression were used to statistical analysis. Results: Cross sectional analysis showed that in women, both HW and HWHtR phenotypes were associated with CKD after controlling for confounders [(OR: 1.37, CI: 1.01-1.86, p < 0.05) and (OR: 1.58, CI: 1.03-2.41, p < 0.05)], respectively. Among men, HW and HWHtR were associated with prevalent CKD in unadjusted and age adjusted models; these associations were not significant after further adjustment for confounders. In prospective analysis, neither HW nor HWHtR phenotypes were significant predictor for CKD progression. Conclusion: HW and HWHtR phenotypes were associated with prevalent CKD in cross sectional setting. In prospective analysis HW and HWHtR did not show significant effect in prediction of CKD. (C) 2016 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.