A novel manganese/iodine-catalyzed Ortoleva-King type protocol for the synthesis of imidazo[1,2-a]pyridines and Zolimidine

被引：3
|
作者：
Aneeja, Thaipparambil [1 ]
Philip, Rose Mary [1 ]
Anilkumar, Gopinathan [1 ]
机构：
[1] Mahatma Gandhi Univ, Sch Chem Sci, Priyadarsini Hills PO, Kottayam 686560, Kerala, India
来源：
RESULTS IN CHEMISTRY | 2022年 / 4卷
关键词：
Imidazo[1,2-a]pyridines; Oroleva-King type reaction; Manganese; Iodine; Zolimidine; AGENTS;
D O I：
10.1016/j.rechem.2022.100474
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The first manganese-iodine catalyzed Ortoleva-King type protocol for the synthesis of imidazo[1,2-a]pyridines has been established. This interesting methodology involves the use of less toxic, readily available and easy to handle MnO2 and molecular iodine as the catalytic system. A wide range of aromatic ketones and 2-aminopyridines were tolerated well in this reaction to afford a variety of imidazo[1,2-a]pyridines in moderate to good yields. This one-pot method is efficient towards the direct synthesis of the gastro protective drug, Zolimidine.
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页数：5
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