Binding epitope of human Anti-FcεRI α-chain receptor antibody, RE51, with the blocking activity on IgE-mediated histamine release

被引：0

作者：

Hashiguchi, S ^{[1
]}

Hayashi, T ^{[1
]}

Ito, Y ^{[1
]}

Sugimura, K ^{[1
]}

机构：

[1] Kagoshima Univ, Fac Engn, Dept Bioengn, Kagoshima, Japan

来源：

IMMUNOLOGY 2004: GENOMIC ISSUES, IMMUNE SYSTEM ACTIVATION AND ALLERGY | 2004年

关键词：

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have previously isolated human single-chain Fv antibodies specific to human FcepsilonRI alpha-chain (FceRIa) using human antibody phage display libraries. One of the selected human scFvs, RE51 (formerly described as FcRepsilon-51: Ref. 1), inhibited IgE-mediated histamine release. In this study, we determined the binding epitope of RE51 using two random peptide-phage display libraries.

引用

页码：541 / 544

页数：4

共 3 条

[1] Blocking of Histamine Release and IgE Binding to FcεRI on Human Basophils by Antibodies Produced in Camels
Khaled, Al-Qaoud
Sana, Yousef
Abdulrahman, Rawashdeh
Raida, Khalil
Sami, Abdel-Hafez
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 2015, 7 (06) : 583 - 589
[2] Inhibition of antigen-induced mediator release from IgE-sensitized cells by a monoclonal anti-FcεRI α-chain receptor antibody:: Implications for the involvement of the membrane-proximal α-chain region in FcεRI-mediated cell activation
Nechansky, A
Robertson, MW
Albrecht, BA
Apgar, JR
Kricek, F
JOURNAL OF IMMUNOLOGY, 2001, 166 (10): : 5979 - 5990
[3] Human FcεRIa-specific human single-chain Fv (scFv) antibody with antagonistic activity toward IgE/FcεRIα-binding
Hashiguchi, S
Nakashima, T
Nitani, A
Yoshihara, T
Yoshinaga, K
Ito, Y
Maeda, Y
Sugimura, K
JOURNAL OF BIOCHEMISTRY, 2003, 133 (01): : 43 - 49

← 1 →