Evaluate and Optimize the New in Vitro Intestinal Absorption Models Using Grey Relational Analysis

To extend the limitation of application of everted rat gut sac technology that evaluates and predicts intestinal absorption for the oral durgs, this study established a series of the reforming models and achieved the optimal selection of the models. In this paper, the evaluation and optimization of complicated multiple responses variables of these models can be converted into the optimization of a standardised single variable by means of grey relational analyses technique. The results show that Model V has advantages than other models. Thus, this study has revealed the predominance of the everted rat gut sac combined with the environment of intestinal digestion as an in vitro model of evaluating intestinal absorption, keeping a best allover performance in all. And this also implies that grey theory can be practically applied in the optimal selection of the in vitro models in the pharmaceutical field.