Araloside A, an antiulcer constituent from the root bark of Aralia elata

被引：39
|
作者：
Lee, EB
Kim, OJ
Kang, SS
Jeong, C
机构：
[1] Seoul Natl Univ, Inst Nat Prod Res, Seoul 110460, South Korea
[2] Seoul Natl Univ, Coll Pharm, Seoul 110460, South Korea
[3] Duksung Womens Univ, Coll Pharm, Seoul 132714, South Korea
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2005年 / 28卷 / 03期
关键词：
araloside A; antiulcer activity; Aralia elata; Araliaceae;
D O I：
10.1248/bpb.28.523
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Araloside A, a potent inhibitor of gastric lesion and ulcer formation in rats, was isolated from the root bark of Aralia elata through a bioassay-guided separation procedure. The compound exhibited significant reduction of HCl (.) ethanol-induced gastric lesions and aspirin-induced gastric ulcers at oral doses of 50 and 100 mg/kg, respectively. These activities are comparable to those of cimetidine.
引用
收藏
页码：523 / 526
页数：4
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