Applications of Adductomics in Chemically Induced Adverse Outcomes and Major Emphasis on DNA Adductomics: A Pathbreaking Tool in Biomedical Research

被引：9

作者：

Behl, Tapan ^{[1
]}

Rachamalla, Mahesh ^{[2
]}

Najda, Agnieszka ^{[3
]}

Sehgal, Aayush ^{[1
]}

Singh, Sukhbir ^{[1
]}

Sharma, Neelam ^{[1
]}

Bhatia, Saurabh ^{[4
]}

Al-Harrasi, Ahmed ^{[4
]}

Chigurupati, Sridevi ^{[5
]}

Vargas-De-La-Cruz, Celia ^{[6
,7
]}

Hobani, Yahya Hasan ^{[8
]}

Mohan, Syam ^{[9
]}

Goyal, Amit ^{[10
]}

Katyal, Taruna ^{[11
]}

Solarska, Ewa ^{[12
]}

Bungau, Simona ^{[13
]}

机构：

[1] Chitkara Univ, Chitkara Coll Pharm, Rajpura 140401, Punjab, India

[2] Univ Saskatchewan, Dept Biol, 112 Sci Pl, Saskatoon, SK S7N 5E2, Canada

[3] Univ Life Sci Lublin, Dept Vegetable Crops & Med Plants, PL-20950 Lublin, Poland

[4] Univ Nizwa, Nat & Med Sci Res Ctr, Birkat Al Mauz 33, Nizwa, Oman

[5] Qassim Univ, Coll Pharm, Dept Med Chem & Pharmacognosy, Buraydah 52571, Saudi Arabia

[6] Univ Nacl Mayor San Marcos, Acad Dept Pharmacol Bromatol & Toxicol, Fac Pharm & Biochem, Ctr Latinoamer Ensenanza & Invest Bacteriol Alime, Lima 15001, Peru

[7] Univ Ciencias & Humanidades, E Hlth Res Ctr, Lima 15001, Peru

[8] Jazan Univ, Fac Appl Med Sci, Dept Med Lab Technol, Jazan 114, Saudi Arabia

[9] Jazan Univ, Subst Abuse & Toxicol Res Ctr, Jazan 114, Saudi Arabia

[10] GHG Khalsa Coll Pharm, Ludhiana 141104, Punjab, India

[11] ICMR Head Quarters, RBMCH Div, New Delhi 110029, India

[12] Univ Life Sci Lublin, Fac Food Sci & Biotechnol, Dept Biotechnol Microbiol & Human Nutr, 8 Skromna St, PL-20704 Lublin, Poland

[13] Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410073, Romania

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 18期

关键词：

adductomics; DNA adduct; protein adduct; cancer detection tool; AMPHIPOD MONOPOREIA-AFFINIS; OVARIAN-CANCER PATIENTS; HIGH-THROUGHPUT LIQUID; IN-VITRO; MASS-SPECTROMETRY; PROTEIN ADDUCTS; N-NITROSAMINES; LIPID-PEROXIDATION; COLORECTAL-CANCER; RISK-ASSESSMENT;

D O I：

10.3390/ijms221810141

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adductomics novel and emerging discipline in the toxicological research emphasizes on adducts formed by reactive chemical agents with biological molecules in living organisms. Development in analytical methods propelled the application and utility of adductomics in interdisciplinary sciences. This review endeavors to add a new dimension where comprehensive insights into diverse applications of adductomics in addressing some of society's pressing challenges are provided. Also focuses on diverse applications of adductomics include: forecasting risk of chronic diseases triggered by reactive agents and predicting carcinogenesis induced by tobacco smoking; assessing chemical agents' toxicity and supplementing genotoxicity studies; designing personalized medication and precision treatment in cancer chemotherapy; appraising environmental quality or extent of pollution using biological systems; crafting tools and techniques for diagnosis of diseases and detecting food contaminants; furnishing exposure profile of the individual to electrophiles; and assisting regulatory agencies in risk assessment of reactive chemical agents. Characterizing adducts that are present in extremely low concentrations is an exigent task and more over absence of dedicated database to identify adducts is further exacerbating the problem of adduct diagnosis. In addition, there is scope of improvement in sample preparation methods and data processing software and algorithms for accurate assessment of adducts.

引用

页数：23