RNA diversification by a self-reproducing ribozyme revealed by deep sequencing and kinetic modelling

被引：8

作者：

Jeancolas, Cyrille ^{[1
,2
]}

Matsubara, Yoshiya J. ^{[3
]}

Vybornyi, Mykhailo ^{[1
]}

Lambert, Camille N. ^{[1
]}

Blokhuis, Alex ^{[1
,4
]}

Alline, Thomas ^{[1
]}

Griffiths, Andrew D. ^{[1
]}

Ameta, Sandeep ^{[3
]}

Krishna, Sandeep ^{[3
]}

Nghe, Philippe ^{[1
]}

机构：

[1] PSL Univ, ESPCI Paris, Chim Biol Innovat, Lab Biochim,CNRS,ESPCI,UMR 8231, 10 Rue Vauquelin, F-75005 Paris, France

[2] Coll France, Lab Anthropol Sociale, 52 Rue Cardinal Lemoine, F-75005 Paris, France

[3] Natl Ctr Biol Sci, Simons Ctr Study Living Machines, Bellary Rd, Bangalore 560065, Karnataka, India

[4] Univ Groningen, Groningen Inst Evolutionary Life Sci, NL-9747 AG Groningen, Netherlands

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 61期

基金：

欧洲研究理事会;

关键词：

TETRAHYMENA;

D O I：

10.1039/d1cc02290c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We demonstrate that a recombinase ribozyme achieves multiple functions in the same reaction network: self-reproduction, iterative elongation and circularization of other RNAs, leading to synthesis of diverse products predicted by a kinetic model. This shows that key mechanisms can be integrated and controlled toward Darwinian evolution in RNA reaction networks.

引用

页码：7517 / 7520

页数：4

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