Evidence-Based Use of Indomethacin and Ibuprofen in the Neonatal Intensive Care Unit

被引：36

作者：

Johnston, Palmer G. ^{[2
]}

Gillam-Krakauer, Maria ^{[2
]}

Fuller, M. Paige ^{[3
]}

Reese, Jeff ^{[1
,2
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Cell & Dev Biol, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Med Ctr, Dept Pediat, Div Neonatol, Nashville, TN 37232 USA

[3] Monroe Carell Jr Childrens Hosp Vanderbilt, Dept Pharm, Nashville, TN 37232 USA

来源：

CLINICS IN PERINATOLOGY | 2012年 / 39卷 / 01期

关键词：

Patent ductus arteriosus (PDA); Hemodynamically significant PDA (hsPDA); Indomethacin; Ibuprofen; Prematurity; Intraventricular hemorrhage (IVH); Necrotizing enterocolitis (NEC); Spontaneous intestinal perforation (SIP); PATENT DUCTUS-ARTERIOSUS; BIRTH-WEIGHT INFANTS; BLOOD-FLOW-VELOCITY; LOW-DOSE INDOMETHACIN; RESPIRATORY-DISTRESS-SYNDROME; PLACEBO-CONTROLLED TRIAL; MONTHS CORRECTED AGE; ACUTE-RENAL-FAILURE; PRETERM INFANTS; INTRAVENTRICULAR HEMORRHAGE;

D O I：

10.1016/j.clp.2011.12.002

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Indomethacin and ibuprofen are potent inhibitors of prostaglandin synthesis. Neonates have been exposed to these compounds for more than 3 decades. Indomethacin is commonly used to prevent intraventricular hemorrhage (IVH), and both drugs are prescribed for the treatment or prevention of patent ductus arteriosus (PDA). This review examines the basis for indomethacin and ibuprofen use in the neonatal intensive care population. Despite the call for restrained use of each drug, the most immature infants are likely to need pharmacologic approaches to reduce high-grade IVH, avoid the need for PDA ligation, and preserve the opportunity for an optimal outcome.

引用

页码：111 / +

页数：27

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