Impact of weight loss on cancer patients' quality of life at the beginning of the chemotherapy

被引:15
|
作者
Alvaro Sanz, Elena [1 ]
Abiles, Jimena [1 ]
Garrido Siles, Margarita [1 ]
Perez Ruiz, Elisabeth [2 ]
Alcaide Garcia, Julia [2 ]
Rueda Dominguez, Antonio [3 ]
机构
[1] Hosp Costa Sol, Area Farm & Nutr, Agencia Sanitaria Costa Sol A7,Km 187, Malaga 29603, Spain
[2] Hosp Costa Sol, Oncol Serv, A7,Km 187, Malaga 29603, Spain
[3] IBIMA, UGCI Oncol Med Hosp Univ Reg & Virgen Victoria, P Limonar 2,Bq3,5 A, Malaga, Spain
关键词
Quality of life; Body-weight trajectory; Nutritional Status; Cachexia; NUTRITIONAL-STATUS; NECK-CANCER; MALNUTRITION; PREVALENCE; INTERVENTION; DETERMINANTS; ASSOCIATION; GUIDELINES; CACHEXIA; THERAPY;
D O I
10.1007/s00520-020-05496-9
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose Among the prognostic factors relevant to the condition of oncological patients, nutritional status (NS) has the greatest single impact on quality of life (QL). The goals of our study were to evaluate the influence of NS, weight loss (WL), and the presence of cachexia, prior to the initiation of chemotherapy, on the patient's QL. Methods Adult patients (aged >= 18 years) diagnosed with solid tumours for whom chemotherapy was started between April 2016 and June 2017 were eligible for inclusion in the study. They were asked to complete a QL questionnaire (Functional Assessment of Cancer Treatment (FACT-G)) at the beginning. The presence or absence of cachexia was evaluated at the outset, following the definition proposed by Fearon and nutritional assessment by the Patient-Generated Subjective Global Assessment (PG-SGA) scale. Results A total of 177 patients completed the FACT-G, the 60% receiving curative therapy. At the start of the treatment, 58.2% of patients had experienced WL, with an average of 4.4 +/- 7.4%, and 19% were at risk of malnutrition. Patient who presented cachexia at diagnosis, were treated with palliative intention, had a Nutriscore >= 5 points or presented malnutrition in accordance with PG-SGA had a poorer QL (p < 0.05). Greater WL was associated with a worsened QL (p = 0.001). Breast cancer patients presented an inverse correlation between the %WL and the initial score in the FACT-G (r = - 0.304, p = 0.023), whereas no such correlation was observed for the other types of tumour (r = - 0.012, p = 0.892). Conclusions These results underline the relation of NS before starting chemotherapy and QL. Greater WL was associated with a worsened QL, especially in women with breast cancer.
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收藏
页码:627 / 634
页数:8
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