Recent Mumps Outbreaks in Vaccinated Populations: No Evidence of Immune Escape

被引：82

作者：

Rubin, Steven A. ^{[1
]}

Link, Malen A. ^{[1
]}

Sauder, Christian J. ^{[1
]}

Zhang, Cheryl ^{[1
]}

Ngo, Laurie ^{[1
]}

Rima, Bert K. ^{[2
]}

Duprex, W. Paul ^{[3
]}

机构：

[1] US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20014 USA

[2] Queens Univ Belfast, Sch Med Dent & Biomed Sci, Belfast, Antrim, North Ireland

[3] Boston Univ, Sch Med, Boston, MA 02118 USA

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 01期

关键词：

JERYL-LYNN; MONOCLONAL-ANTIBODIES; UNIVERSITY-STUDENTS; VIRUS-VACCINE; STRAIN; SEQUENCE; LIVE; PERSISTENCE; MEASLES; PROTEIN;

D O I：

10.1128/JVI.06125-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recently, numerous large-scale mumps outbreaks have occurred in vaccinated populations. Clinical isolates sequenced from these outbreaks have invariably been of genotypes distinct from those of vaccine viruses, raising concern that certain mumps virus strains may escape vaccine-induced immunity. To investigate this concern, sera obtained from children 6 weeks after receipt of measles, mumps, and rubella (MMR) vaccine were tested for the ability to neutralize a carefully selected group of genetically diverse mumps virus strains. Although the geometric mean neutralizing antibody titer of the sera was lower against some virus strains than others, all viruses were readily neutralized, arguing against immune escape.

引用

页码：615 / 620

页数：6

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