The effects of β3-adrenoceptor agonist CL-316,243 on adiponectin, adiponectin receptors and tumor necrosis factor-α expressions in adipose tissues of obese diabetic KKAy mice

被引：25

作者：

Fu, Ling ^{[1
]}

Isobe, Kazumasa ^{[1
]}

Zeng, Qin ^{[1
]}

Suzukawa, Kazumi ^{[1
]}

Takekoshi, Kazuhiro ^{[1
]}

Kawakami, Yasushi ^{[1
]}

机构：

[1] Univ Tsukuba, Inst Clin Med, Dept Clin Pathol, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki 3058575, Japan

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2008年 / 584卷 / 01期

关键词：

beta-adrenoceptor; adiponectin; adiponectin receptor; tumor necrosis factor-a; adipose tissue; insulin resistance;

D O I：

10.1016/j.ejphar.2008.01.028

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigated the effects of beta(3)-adrenoceptor agonist, 5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL-316,243) in obese diabetic KKAy mice. Two weeks' subcutaneous administration of CL-316,243 reduced serum levels of glucose, insulin, triglyceride, free fatty acid and tumor necrosis factor-alpha (TNF-alpha), and increased adiponectin. Adiponectin, adiponectin receptors and beta(3)-adrenoceptor mRNA expressions were reduced in epididymal white adipose tissue in KKAy mice, and CL-316,243 recovered these mRNA expressions. Meanwhile, CL-316,243 suppressed the overexpressed mRNA level of TNF-alpha in both epididymal white adipose tissue and brown adipose tissue. These data suggest that the normalization of adiponectin, adiponectin receptors and TNF-alpha may result in the amelioration of obesity-induced insulin resistance. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：202 / 206

页数：5