Disrupting off-target Cas9 activity in the liver

被引：3
|
作者：
Dilliard, Sean A. [1 ]
Siegwart, Daniel J. [1 ]
机构：
[1] Univ Texas Southwestern Med Ctr, Simmons Comprehens Canc Ctr, Dept Biochem, Dallas, TX 75390 USA
来源：
NATURE BIOMEDICAL ENGINEERING | 2022年 / 6卷 / 02期
关键词：
D O I：
10.1038/s41551-022-00848-8
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
[No abstract available]
引用
收藏
页码：106 / 107
页数：2
相关论文
共 50 条
  • [1] Disrupting off-target Cas9 activity in the liver
    Sean A. Dilliard
    Daniel J. Siegwart
    Nature Biomedical Engineering, 2022, 6 : 106 - 107
  • [2] Structural basis for Cas9 off-target activity
    Pacesa, Martin
    Lin, Chun-Han
    Clery, Antoine
    Saha, Aakash
    Arantes, Pablo R.
    Bargsten, Katja
    Irby, Matthew J.
    Allain, Frederic H. -T.
    Palermo, Giulia
    Cameron, Peter
    Donohoue, Paul D.
    Jinek, Martin
    CELL, 2022, 185 (22) : 4067 - +
  • [3] Structural basis for Cas9 off-target activity
    Pacesa, Martin
    Lin, Chun-Han
    Clery, Antoine
    Saha, Aakash
    Arantes, Pablo R.
    Bargsten, Katja
    Irby, Matthew J.
    Allain, Frederic H-T
    Palermo, Giulia
    Cameron, Peter
    Donohoue, Paul D.
    Jinek, Martin
    CELL, 2022, 185 (23) : 4067 - +
  • [4] Off-target Cas9 crystallized
    Thomas, Tim
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2022, 29 (12) : 1147 - 1147
  • [5] Off-target Cas9 crystallized
    Tim Thomas
    Nature Structural & Molecular Biology, 2022, 29 : 1147 - 1147
  • [6] DNA stretching induces Cas9 off-target activity
    Newton, Matthew D.
    Taylor, Benjamin J.
    Driessen, Rosalie P. C.
    Roos, Leonie
    Cvetesic, Nevena
    Allyjaun, Shenaz
    Lenhard, Boris
    Cuomo, Maria Emanuela
    Rueda, David S.
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2019, 26 (03) : 185 - +
  • [7] DNA stretching induces Cas9 off-target activity
    Matthew D. Newton
    Benjamin J. Taylor
    Rosalie P. C. Driessen
    Leonie Roos
    Nevena Cvetesic
    Shenaz Allyjaun
    Boris Lenhard
    Maria Emanuela Cuomo
    David S. Rueda
    Nature Structural & Molecular Biology, 2019, 26 : 185 - 192
  • [8] DNA Stretching and Supercoiling Induces Cas9 Off-Target Activity
    Newton, Matt D.
    King, Graeme
    Taylor, Benjamin J.
    Cuomo, Emanuela M.
    Rueda, David S.
    BIOPHYSICAL JOURNAL, 2021, 120 (03) : 34A - 35A
  • [9] Off-target Effect of CRISPR/Cas9 and Optimization
    Guo Quan-Juan
    Han Qiu-Ju
    Zhang Jian
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2018, 45 (08) : 798 - 807
  • [10] Cas9 loosens its grip on off-target sites
    Christopher E Nelson
    Charles A Gersbach
    Nature Biotechnology, 2016, 34 : 299 - 299
12345