Short and efficient hemisynthesis of α-eudesmol and cryptomeridiol

被引：29
|
作者：
Tebbaa, Mohamed [1 ,2 ]
El Hakmaoui, Ahmed [1 ]
Benharref, Ahmed [2 ]
Akssira, Mohamed [1 ]
机构：
[1] Univ Hassan 2, Fac Sci & Tech, LCBA, URAC22, Mohammedia Casablanca 28800, Mohammedia, Morocco
[2] Univ Cadi Ayyad, Fac Sci Semlalia, Lab Chim Biomol Subst Nat & Reactivite, URAC16, Marrakech 40000, Morocco
来源：
TETRAHEDRON LETTERS | 2011年 / 52卷 / 29期
关键词：
SESQUITERPENE LACTONES; CONSTITUENTS; ACIDS; ESTERS;
D O I：
10.1016/j.tetlet.2011.05.064
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The aerial part of Dittrichia viscosa yielded two sesquiterpenes, isocostic acid (1) and ilicic acid (2), on multigram scale. These acids are appropriate starting materials for short and facile syntheses of a-eudesmol (5) and cryptomeridiol (6), natural products featuring anti-Alzheimer and anti-spasmodic properties. Compounds 5 and 6 were obtained in three steps in overall yields of 70% and 52%, respectively. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3769 / 3771
页数：3
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