Caffeine-related genes influence anxiety disorders in children and adults with ADHD

被引：0

作者：

Fraporti, Thailan Teles ^{[1
]}

Bandeira, Cibele Edom ^{[2
,3
,4
]}

Tovo-Rodrigues, Luciana ^{[5
]}

Martins-Silva, Thais ^{[5
]}

Hutz, Mara Helena ^{[2
,3
,4
]}

Rohde, Luis Augusto ^{[4
,6
,7
]}

Dotto Bau, Claiton Henrique ^{[2
,3
,4
,7
]}

Grevet, Eugenio Horacio ^{[4
,7
,8
]}

da Silva, Bruna Santos ^{[2
,3
,4
]}

Rovaris, Diego Luiz ^{[9
,10
]}

Dresch, Fabiane ^{[11
]}

Contini, Veronica ^{[11
]}

Genro, Julia Pasqualini ^{[1
]}

机构：

[1] Univ Fed Ciencias Saude Porto Alegre, Grad Program Biosci, Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Inst Biosci, Dept Genet, Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande Rio Grande do Sul, Grad Program Genet & Mol Biol, Porto Alegre, RS, Brazil

[4] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, ADHD & Dev Psychiat Programs, Porto Alegre, RS, Brazil

[5] Univ Fed Pelotas, Postgrad Program Epidemiol, Pelotas, RS, Brazil

[6] Natl Inst Dev Psychiat Children & Adolescents, Sao Paulo, Brazil

[7] Univ Fed Rio Grande do Sul, Grad Program Psychiat & Behav Sci, Porto Alegre, RS, Brazil

[8] Univ Fed Rio Grande do Sul, Fac Med, Dept Psychiat & Legal Med, Porto Alegre, RS, Brazil

[9] Univ Sao Paulo, Dept Physiol & Biophys, Inst Ciencias Biomed, Sao Paulo, Brazil

[10] Univ Sao Paulo, Grad Program Human Physiol, Inst Ciencias Biomed, Sao Paulo, Brazil

[11] Univ Vale Taquari Univates, Grad Program Biotechnol, Lajeado, Brazil

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 2022年 / 145卷

关键词：

Attention-deficit; hyperactivity disorder; Anxiety disorders; Caffeine; Gene-set; DEFICIT HYPERACTIVITY DISORDER; PANIC DISORDER; ANIMAL-MODEL; ATTENTION; ASSOCIATION; ADORA2A; POLYMORPHISMS; RECEPTOR; CONSUMPTION; BLOOD;

D O I：

10.1016/j.jpsychires.2021.11.004

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Attention-deficit/hyperactivity disorder (ADHD) and anxiety disorders (AD) frequently co-occur, increasing morbidity and challenging treatment. Caffeine is a central nervous system stimulant and acts in the brain through adenosine receptors, influencing attention, alertness, and anxiety. In the present study, we performed a gene-set analysis to verify if genes related to caffeine response are associated with anxiety disorders in 240 children and 406 adults with ADHD. We demonstrated an association between the gene-set with AD in children (P = 0.0054) and with the number of anxiety disorders in adults (P = 0.0197). In order to test if this effect is a result of anxiety in general or is related to AD comorbid with ADHD, we evaluated the association between caffeine gene-set with AD in an adult control sample. The gene-set was neither associated with the AD presence (P = 0.3008) nor with the number of AD (P = 0.5594) in this control sample. We also test this gene set with ADHD (n = 55,374) and AD (n = 18,186) GWAS summary statistics, and we did not observe significant results with ADHD (P = 0.5587) or AD (P = 0.3930). These findings suggest the caffeine-related genes play a role in the etiology of an anxiety disorder phenotype present in children and adults with ADHD.

引用

页码：353 / 360

页数：8

共 50 条

[1] CAFFEINE-RELATED GENES INFLUENCE ANXIETY DISORDERS IN CHILDREN AND ADULTS WITH ADHD
Fraporti, Thailan
Bandeira, Cibele Edom
Tovo-Rodrigues, Luciana
Martins-Silva, Thais
Hutz, Mara Helena
Rohde, Luis Augusto
Dotto Bau, Claiton Henrique
Grevet, Eugenio Horacio
da Silva, Bruna Santos
Rovaris, Diego Luiz
Dresch, Fabiane
Contini, Veonica
Genro, Julia Pasqualini
[J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2021, 51 : E194 - E195
[2] Comorbid anxiety disorders in ADHD children
Chutko, L. S.
Aikbekov, K. A.
Lapshina, O. V.
Surushkina, S. Yu.
Nikishena, I. S.
Yakovenko, E. A.
Anisimova, T. I.
[J]. ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA, 2008, 108 (03): : 49 - 52
[3] Coffee, Caffeine-Related Genes, and Parkinson's Disease: A Case-Control Study
Facheris, Maurizio F.
Schneider, Nicole K.
Lesnick, Timothy G.
de Andrade, Mariza
Cunningham, Julie M.
Rocca, Walter A.
Maraganore, Demetrius M.
[J]. MOVEMENT DISORDERS, 2008, 23 (14) : 2033 - 2040
[4] Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?
Middeldorp, C. M.
Slof-Op 't Landt, M. C. T.
Medland, S. E.
van Beijsterveldt, C. E. M.
Bartels, M.
Willemsen, G.
Hottenga, J. -J.
de Geus, E. J. C.
Suchiman, H. E. D.
Dolan, C. V.
Neale, M. C.
Slagboom, P. E.
Boomsma, D. I.
[J]. GENES BRAIN AND BEHAVIOR, 2010, 9 (07) : 808 - 816
[5] Impact of anxiety disorders on attentional functions in children with ADHD
Vloet, Timo D.
Konrad, Kerstin
Herpertz-Dahlmann, Beate
Polier, Georg G.
Guenther, Thomas
[J]. JOURNAL OF AFFECTIVE DISORDERS, 2010, 124 (03) : 283 - 290
[6] Does ADHD moderate the manifestation of anxiety disorders in children?
Hammerness, Paul
Geller, Daniel
Petty, Carter
Lamb, Alexis
Bristol, Elyssa
Biederman, Joseph
[J]. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 2010, 19 (02) : 107 - 112
[7] Does ADHD moderate the manifestation of anxiety disorders in children?
Paul Hammerness
Daniel Geller
Carter Petty
Alexis Lamb
Elyssa Bristol
Joseph Biederman
[J]. European Child & Adolescent Psychiatry, 2010, 19 : 107 - 112
[8] Managing ADHD in children, adolescents, and adults with comorbid anxiety
Adler, Lenard A.
Barkley, Russell A.
Newcorn, Jeffrey H.
Spencer, Thomas J.
Weiss, Margaret D.
[J]. JOURNAL OF CLINICAL PSYCHIATRY, 2007, 68 (03) : 451 - 462
[9] Comparison of Neurological and Cognitive Deficits in Children With ADHD and Anxiety Disorders
Yurtbasi, Pinar
Aldemir, Secil
Bakir, Meryem Gul Teksin
Aktas, Sule
Ayvaz, Fatma Betul
Satilmis, Seyma Pistav
Munir, Kerim
[J]. JOURNAL OF ATTENTION DISORDERS, 2018, 22 (05) : 472 - 485
[10] Comorbid ADHD: Implications for the Treatment of Anxiety Disorders in Children and Adolescents
Halldorsdottir, Thorhildur
Ollendick, Thomas H.
[J]. COGNITIVE AND BEHAVIORAL PRACTICE, 2014, 21 (03) : 310 - 322

← 1 2 3 4 5 →