Highly efficient synthesis of triazolo[1,2-a]indazole-triones and novel spiro triazolo[1,2-a]indazole-tetraones under solvent-free conditions

被引：99
|
作者：
Hasaninejad, Alireza [1 ]
Zare, Abdolkarim [2 ]
Shekouhy, Mohsen [1 ]
机构：
[1] Persian Gulf Univ, Fac Sci, Dept Chem, Bushehr 75169, Iran
[2] PNU, Dept Chem, Bushehr 1698, Iran
来源：
TETRAHEDRON | 2011年 / 67卷 / 02期
关键词：
Combinatorial chemistry; Multi-component reaction; PEG-SO3H; Urazole; Triazolo[1,2-a]indazole-triones; Spiro triazolo[1,2-a]indazole-tetraone; BIGINELLI DIHYDROPYRIMIDINE SYNTHESIS; HETEROGENEOUS CATALYTIC-SYSTEM; SILICA SULFURIC-ACID; CARBONYL-COMPOUNDS; ATOM ECONOMY; MILD; CONDENSATION; DERIVATIVES; CHEMISTRY; LIBRARIES;
D O I：
10.1016/j.tet.2010.11.029
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new, convenient, and high yielding procedure for the synthesis of triazolo[1,2-a]indazole-triones by the condensation reaction between dimedone, aryl aldehydes, and ueazoles in the presence of a catalytic amount of sulfonated polyethylene glycol (PEG-SO3H) as a highly stable and reusable eco-friendly degradable polymeric catalyst is described under solvent-free conditions. This procedure has also been applied successfully for the synthesis of novel Spiro triazolo[1,2-a]indazole-tetraones. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：390 / 400
页数：11
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