Anti-inflammatory lanostane-type triterpene acids from Piptoporus betulinus

被引：56
|
作者：
Kamo, T [1 ]
Asanoma, M [1 ]
Shibata, H [1 ]
Hirota, M [1 ]
机构：
[1] Shinshu Univ, Fac Agr, Dept Biosci & Biotechnol, Nagano 3994598, Japan
来源：
JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 08期
关键词：
D O I：
10.1021/np0300479
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Six lanostane-type triterpene acids were isolated from the fruiting bodies of Piptoporus betulinus. They were identified as polyporenic acids A (1) and C (2), three derivatives of polyporenic acid A (3-5), and a novel compound, (+)-12alpha,28-dihydroxy-3alpha-(3'-hydroxy-3'-methylglutaryloxy)-24-methyllanosta-8,24(31)dien-26-oic acid (6). All these compounds suppressed the 12-O-tetradecanoylphorbol-13-acetate (TPA)induced edema on mouse ears by 49-86% with a 400 nmol/ear application.
引用
收藏
页码：1104 / 1106
页数：3
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