Comparison of rifabutin susceptibility and rpoB mutations in multi-drug-resistant Mycobacterium tuberculosis strains by DNA sequencing and the line probe assay

被引：18
|
作者：
Yoshida, Shiomi [1 ]
Suzuki, Katsuhiro [1 ]
Iwamoto, Tomotada [3 ]
Tsuyuguchi, Kazunari [1 ]
Tomita, Motohisa [2 ]
Okada, Masaji [1 ]
Sakatani, Mitsunori [4 ]
机构：
[1] Natl Hosp Org, Clin Res Ctr, Kinki Chuo Chest Med Ctr, Sakai, Osaka 5918555, Japan
[2] Natl Hosp Org, Dept Clin Microbiol, Kinki Chuo Chest Med Ctr, Sakai, Osaka 5918555, Japan
[3] Kobe Inst Hlth, Dept Microbiol, Chuo Ku, Kobe, Hyogo 6500046, Japan
[4] Natl Hosp Org, Dept Resp Med, Kinki Chuo Chest Med Ctr, Kita Ku, Sakai, Osaka 5918555, Japan
来源：
JOURNAL OF INFECTION AND CHEMOTHERAPY | 2010年 / 16卷 / 05期
关键词：
Tuberculosis; Drug resistance; Rifabutin; rpoB; Line probe assay; RIFAMYCIN CROSS-RESISTANCE; IN-VITRO ACTIVITY; RIFAMPICIN; COMPLEX;
D O I：
10.1007/s10156-010-0057-5
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We compared rifabutin susceptibility and rpoB mutations in 98 multi-drug-resistant strains of Mycobacterium tuberculosis (MDR-TB) by DNA sequencing and with a line probe assay using the commercially available INNO-LiPA Rif. TB kit (the LiPA). Our results indicated that rifabutin continues to remain active against MDR-TB strains harboring certain genetic alterations and also that the LiPA might be useful in identifying MDR-TB strains susceptible to rifabutin.
引用
收藏
页码：360 / 363
页数：4
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