In vitro and ex vivo models for evaluating vaginal drug delivery systems

被引：15
|
作者：
Shapiro, Rachel L. [1 ,2 ]
DeLong, Kevin [1 ,3 ]
Zulfiqar, Fareeha [1 ,3 ]
Carter, Davell [1 ,4 ]
Better, Marina [1 ,4 ]
Ensign, Laura M. [1 ,3 ,4 ,5 ,6 ,7 ,8 ,9 ]
机构：
[1] Johns Hopkins Univ, Wilmer Eye Inst, Sch Med, Ctr Nanomed, 400 N Broadway, Baltimore, MD 21231 USA
[2] Johns Hopkins Univ, Dept Chem & Biomol Engn, 3400 N Charles St, Baltimore, MD 21218 USA
[3] Johns Hopkins Univ, Wilmer Eye Inst, Dept Ophthalmol, Sch Med, 1800 Orleans St, Baltimore, MD 21287 USA
[4] Johns Hopkins Univ, Dept Pharmacol & Mol Sci, Sch Med, 725 N Wolfe St, Baltimore, MD 21287 USA
[5] Johns Hopkins Univ, Dept Chem & Biomol Engn, 3400 N Charles St, Baltimore, MD 21218 USA
[6] Johns Hopkins Univ, Sch Med, Dept Gynecol & Obstet, 1800 Orleans St, Baltimore, MD 21287 USA
[7] Johns Hopkins Univ, Sch Med, Dept Infect Dis, 1800 Orleans St, Baltimore, MD 21287 USA
[8] Johns Hopkins Univ, Sch Med, Dept Oncol, 1800 Orleans St, Baltimore, MD 21287 USA
[9] Johns Hopkins Univ, Dept Biomed Engn, 3400 N Charles St, Baltimore, MD 21218 USA
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2022年 / 191卷
基金：
美国国家卫生研究院;
关键词：
Cervicovaginal mucus; Microbicides; Preterm birth; Mucus penetrating particles; Reproductive tract cancer; CERVICAL-MUCUS PLUG; HUMAN CERVICOVAGINAL MUCUS; BACTERIAL VAGINOSIS; BARRIER PROPERTIES; POLYMERIC NANOPARTICLES; MOLECULAR-MECHANISM; SYNTHETIC-POLYMERS; MUCIN SECRETION; TRANSPORT; CELLS;
D O I：
10.1016/j.addr.2022.114543
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Vaginal drug delivery systems are often preferred for treating a variety of diseases and conditions of the female reproductive tract (FRT), as delivery can be more targeted with less systemic side effects. However, there are many anatomical and biological barriers to effective treatment via the vaginal route. Further, biocompatibility with the local tissue and microbial microenvironment is desired. A variety of in vitro and ex vivo models are described herein for evaluating the physicochemical properties and tox-icity profile of vaginal drug delivery systems. Deciding whether to utilize organoids in vitro or fresh human cervicovaginal mucus ex vivo requires careful consideration of the intended use and the formula-tion characteristics. Optimally, in vitro and ex vivo experimentation will inform or predict in vivo perfor-mance, and examples are given that describe utilization of a range of methods from in vitro to in vivo. Lastly, we highlight more advanced model systems for other mucosa as inspiration for the future in model development for the FRT. (c) 2022 Elsevier B.V. All rights reserved.
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页数：17
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