Early Mechanisms of Glucose Improvement following Laparoscopic Ileal Interposition Associated with a Sleeve Gastrectomy Evaluated by the Euglycemic Hyperinsulinemic Clamp in Type 2 Diabetic Patients with BMI below 35

Background: Laparoscopic ileal interposition associated with a sleeve gastrectomy (LII-SG) is a safe and effective operation for the treatment of type 2 diabetic (T2DM) patients with BMI below 35. The aim of this study was to evaluate insulin sensitivity (IS) and beta-cell function using the euglycemic hyperinsulinemic clamp (EHC) with the intravenous glucose tolerance test (IVGTT). Methods: This was a prospective study of 24 T2DM patients submitted to a 3-hour EHC-IVGTT before and 1 month after LII-SG. Mean BMI was 29.0, mean age was 54.8 years and mean duration of T2DM was 10.2 years; insulin therapy was used by 62.5% of the patients. Results: Mean BMI decreased from 29.0 to 25.8 (p < 0.001). Mean fasting plasma glucose and mean postprandial glucose were 202 and 251.3 mg/dl and dropped to 127.7 and 131.8 mg/dl (p < 0.001), respectively. Mean preoperative IS was 1.4 mmol.min(-1).nmol(-1) and increased to 2.2 mmol.min(-1).nmol(-1) postoperatively (p < 0.001). Mean C-peptide AUC was 488 pmol.nmol(-1) and increased to 777 pmol.nmol(-1) (p = 0.37). The disposition index increased from 9.4 to 36.4 postoperatively (p = 0.01). Conclusions: According to the clamp technique, II-SG significantly improved IS and beta-cell function as early as 30 days postoperatively in a T2DM population with a BMI of 21.9-33.8. Copyright (C) 2011 S. Karger AG, Basel