Effects on metabolic variables after 12-month treatment with a new once-a-week sustained-release recombinant growth hormone (GH: LB03002) in patients with GH deficiency

被引：12

作者：

Roemmler, J. ^{[1
]}

Gockel, A. ^{[1
]}

Otto, B. ^{[1
]}

Bidlingmaier, M. ^{[1
]}

Schopohl, J. ^{[1
]}

机构：

[1] Univ Munich, Dept Internal Med Endocrinol Innenstadt, D-80336 Munich, Germany

来源：

CLINICAL ENDOCRINOLOGY | 2012年 / 76卷 / 01期

关键词：

BODY-FAT DISTRIBUTION; BONE-MINERAL DENSITY; HEALTHY ELDERLY-MEN; INSULIN SENSITIVITY; REPLACEMENT THERAPY; HYPOPITUITARY PATIENTS; GHRELIN LEVELS; AND/OR TESTOSTERONE; CARDIOVASCULAR RISK; GLUCOSE-TOLERANCE;

D O I：

10.1111/j.1365-2265.2011.04146.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction GH substitution in GH deficiency (GHD) must be subcutaneously administered daily. A new sustained-release formulation of GH (LB03002) has been developed, which has to be injected once a week. As a substudy to the phase III study, we performed this prospective study to evaluate the influence of LB03002 on metabolic variables and hormones.

引用

页码：88 / 95

页数：8

共 8 条

[1] Efficacy and safety of LB03002, a once-weekly sustained-release human GH for 12-month treatment in Korean children with GH deficiency
Hwang, Jin Soon
Lee, Hae Sang
Chung, Woo Yeong
Han, Heon-Seok
Jin, Dong-Kyu
Kim, Ho-Seong
Ko, Cheol-Woo
Lee, Byung-Churl
Lee, Dae-Yeol
Lee, Kee-Hyoung
Shin, Jeh-Hoon
Suh, Byung-Kyu
Yoo, Han-Wook
Ji, Hyi-Jeong
Lee, Jin-Hwa
Bae, Yoon Ju
Kim, Duk-Hee
Yang, Sei Won
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2013, 169 (02) : 179 - 185
[2] Comparative pharmacokinetics and pharmacodynamics of a new sustained-release growth hormone (GH), LB03002, versus daily GH in adults with GH deficiency
Bidlingmaier, Martin
Kim, John
Savoy, Conrad
Kim, Myung J.
Ebrecht, Nils
de la Motte, Stephan
Strasburger, Christian J.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (08): : 2926 - 2930
[3] Pharmacokinetic and pharmacodynamic profile of a new sustained-release GH formulation, LB03002, in children with GH deficiency
Peter, Ferenc
Savoy, Conrad
Ji, Hyi-Jeong
Juhasz, Mihaly
Bidlingmaier, Martin
Saenger, Paul
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2009, 160 (03) : 349 - 355
[4] 12-Month effects of once-weekly sustained-release growth hormone treatment in adults with GH deficiency
Beverly M. K. Biller
Hyi-Jeong Ji
Hyunji Ahn
Conrad Savoy
E. Christine Siepl
Vera Popovic
Mihail Coculescu
Josefine Roemmler
Catalin Gavrila
David M. Cook
Christian J. Strasburger
Pituitary, 2013, 16 : 311 - 318
[5] 12-Month effects of once-weekly sustained-release growth hormone treatment in adults with GH deficiency
Biller, Beverly M. K.
Ji, Hyi-Jeong
Ahn, Hyunji
Savoy, Conrad
Siepl, E. Christine
Popovic, Vera
Coculescu, Mihail
Roemmler, Josefine
Gavrila, Catalin
Cook, David M.
Strasburger, Christian J.
PITUITARY, 2013, 16 (03) : 311 - 318
[6] Three-Year Efficacy and Safety of LB03002, a Once-Weekly Sustained-Release Growth Hormone (GH) Preparation, in Prepubertal Children with GH Deficiency (GHD)
Peter, Ferenc
Bidlingmaier, Martin
Savoy, Conrad
Ji, Hyi-Jeong
Saenger, Paul H.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2012, 97 (02): : 400 - 407
[7] Analysis of safety and efficacy of a novel sustained release rhGH (LB03002) given once-a-week for up to 24 months to prepubertal children with growth hormone deficiency (GHD)
Peter, F.
Savoy, C.
Kim, J.
Ji, H. J.
Juhasz, M.
Saenger, P.
HORMONE RESEARCH, 2006, 65 : 30 - 30
[8] Metabolic Parameters and Adipokine Profi le in Growth Hormone Defi cient ( GHD) Children Before and After 12-Month GH Treatment
Meazza, C.
Elsedfy, H. H.
Pagani, S.
Bozzola, E.
El Kholy, M.
Bozzola, M.
HORMONE AND METABOLIC RESEARCH, 2014, 46 (03) : 219 - 223

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